Use of Iron (III) Chloride in the Efficient Preparation of the Alkaloid Kreysigine by Oxidative Coupling

Article abstract of DOI:10.1016/00404-0399(50)1037I-

Reaction of the isoquinoline (1) with iron (III) chloride in dichloromethane followed by reductive treatment with methanol gives kreysigine (4) in 71percent yield; (2) gives (4) in lower yield as does treatment with water instead of methanol; (8) is the p