SYNTHESIS OF ESTERS OF 2-SUBSTITUTED 4-KETOPENTANOIC ACIDS BY THE ALKYLATION OF CH-ACIDS USING CHLOROACETONE UNDER PHASE TRANSFER CATALYSIS CONDITIONS

Article abstract of DOI:10.1007/BF00960682

An improved method was developed for the synthesis of ethyl esters of 2-substituted 4-ketopentanoic acids by the alkylation of CH2(X)CO2Et using chloroacetone in the liquid-solid KOH (K2CO3 or Na2CO3)-DMF-PhCH2(Et)3NCl system.