Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases

DOI: 10.1016/S0960-894X(98)00738-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 375 - 380 (1999)

Update date:2022-08-17

Topics:

Authors:

Yu, Xiang Y.

Hill, Jason M.

Yu, Guixue

Wang, Weiheng

Kluge, Arthur F.

Wendler, Phil

Gallant, Paul

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Article abstract of DOI:10.1016/S0960-894X(98)00738-0

A series of novel aminoacyl adenylate mimics has been prepared and evaluated for their inhibitory activity against aminoacyl-tRNA synthetases. Several of these thiazole derivatives displayed potent and selective enzyme activity against both Gram-positive and Gram-negative bacteria.

Full text of DOI:10.1016/S0960-894X(98)00738-0

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