A practical manufacturing synthesis of 1-(R)-hydroxymethyl-DTPA: An important intermediate in the synthesis of MRI contrast agents

Article abstract of DOI:10.1080/00397919908086243

An efficient synthesis of alcohol 2 is described from L-Serine (OMe) in four synthetic steps. The process uses readily available reagents and is suitable for manufacturing.

Full text of DOI:10.1080/00397919908086243

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic Organic
Chemistry
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A Practical Manufacturing Synthesis
of 1-(R)-Hydroxymethyl-Dtpa: An
Important Intermediate in the
Synthesis of MRI Contrast Agents
John C. Amedio a , Paul J. Bernard a , Mark Fountain a
Gerritt Van Wagenen a
&
a Chemical Development , EPIX Medical, Inc. , 71 Rogers St,
Cambridge, MA, 02142-1118, USA
Published online: 17 Sep 2007.
To cite this article: John C. Amedio , Paul J. Bernard , Mark Fountain & Gerritt Van Wagenen
(1999) A Practical Manufacturing Synthesis of 1-(R)-Hydroxymethyl-Dtpa: An Important
Intermediate in the Synthesis of MRI Contrast Agents, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 29:14,
2377-2391, DOI: 10.1080/00397919908086243
To link to this article: http://dx.doi.org/10.1080/00397919908086243
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