Synthesis of piperamides and new analogues from natural safrole

Article abstract of DOI:10.1080/00397919908085766

Species of the Piper genus are amply known for their biological activities. This paper describes a new synthetic route for the preparation of piperamides and analogues, using as an efficient precursor, the Brazilian natural product safrole (1). The amides (6a-c) were obtained in 25-32% overall yield.

Full text of DOI:10.1080/00397919908085766

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Synthetic Communications: An
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Organic Chemistry
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Synthesis of Piperamides and
New Analogues from Natural
Safrole
João X. de Araújo Júnior a b , Eliezer J. Barreiro a ,
José P. Parente b & Carlos A. M. Fraga a
a Laboratório de Avaliação e Síntese de
Subst[acaron]ntias Bioativas (LASSBio), Faculdade de
Farmácia, Universidade Federal do Rio de Janeiro,
CP 68006, 21944-970, Rio de Janeiro, RJ, Brazil
b Núcleo de Pesquisa de Produtos Naturais, UFRJ,
Rio de Janeiro, RJ, Brazil
Published online: 17 Sep 2007.
To cite this article: João X. de Araújo Júnior , Eliezer J. Barreiro , José P. Parente &
Carlos A. M. Fraga (1999) Synthesis of Piperamides and New Analogues from Natural
Safrole, Synthetic Communications: An International Journal for Rapid Communication
of Synthetic Organic Chemistry, 29:2, 263-273, DOI: 10.1080/00397919908085766
To link to this article: http://dx.doi.org/10.1080/00397919908085766
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