Synthetic Communications p. 263 - 273 (1999)
Update date:2022-08-10
Topics:
De Araújo Jr., Jo?o X.
Barreiro, Eliezer J.
Parente, José P.
Fraga, Carlos A. M.
Species of the Piper genus are amply known for their biological activities. This paper describes a new synthetic route for the preparation of piperamides and analogues, using as an efficient precursor, the Brazilian natural product safrole (1). The amides (6a-c) were obtained in 25-32% overall yield.
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