Synthesis of a new amphiphilic ortho-carborane as a potential BNCT agent: 4-[N,N-formyl-(ortho-carboranylmethyl)amino]benzoyl-L-glutamic acid

Article abstract of DOI:10.1016/S0040-4039(99)00853-9

A 1,2-dicarba-closo-dodecaboranyl derivative (8) and its disodium salt (9) were prepared from 4-aminobenzoic acid (1). The water solubility and the biological data (toxicity and cell-uptake) of the disodium salt (9) were identified to be enough for clinical trial.