Generation of functional diversity via nitroaldol condensations of α-aminoacid aldehydes - A new and stereocontrolled route to acyclic 1,3-diamino-2-alcohols

Article abstract of DOI:10.1016/0040-4039(95)02359-3

Condensations of N,N-dibenzyl α-amino aldehydes with nitroalkanes mediated by tetrabutylammonium fluoride proceed in excellent yields and selectivities. This affords rapid and stereoselective access to acyclic molecules containing differentiated nitrogen-