Journal of the American Chemical Society p. 7773 - 7779 (1981)
Update date:2022-08-17
Topics:
Ford, H.
Chang, C.-H.
Behrman, E.J.
We have modified the dinucleoside monophosphate, deoxythymidylyldeoxycytidine (d-TpC), by replacement of the exocyclic amino group of cytosine with a series of ligands, H2N(CH2)nN(CH3)CH2CH2N(CH3)2, where n = 2, 4, and 6.The kinetics of the reactions of these modified dinucleoside monophosphates with osmium tetroxide were measured.The modified nucleotides react with osmium tetroxide 4200, 7900, and 1200 times faster than the unmodified species for n = 6, 4, and 2, respectively.The products of the reactions are macrocyclic oxoosmium (VI) esters for which 360-MHz proton NMR spectra are reported.
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