Organic Reactions at High Pressure. A Robinson Annulation Sequence Initiated by Michael Addition of Activated Cycloalkanones with Hindered Enones

Article abstract of DOI:10.1021/jo00172a039

Activated cycloalkanones (ring size = five, six, seven) undergo Michael addition to β,β-disubstituted enones and subsequent aldol cyclization at 15 kbar (1.5 GPa) pressure in acetonitrile containing triethylamine or 1,5-diazabicyclo<4.3.0>non-5-ene to aff