No-carrier-added labeling of the neuroprotective Ebselen with selenium-73 and selenium-75

Article abstract of DOI:10.1002/jlcr.3274

Selenium-73 is a positron emitting non-standard radionuclide, which is suitable for positron emission tomography. A copper-catalyzed reaction allowed no-carrier-added labeling of the anti-inflammatory seleno-organic compound Ebselen with ⁷³Se and ⁷⁵Se under addition of sulfur carrier in a one-step reaction. The new authentically labeled radioselenium molecule is thus available for preclinical evaluation and positron emission tomography studies.