INCORPORATION OF SHIKIMIC ACID INTO p-HYDROXYBENZOIC ACID IN LITHOSPERMUM ERYTHRORHIZON CELL CULTURES

Article abstract of DOI:10.1016/S0031-9422(00)98058-0

<1,7-13C2>Shikimic acid was fed to cell cultures of Lithospermum erythrorhizon which accumulate p-hydroxybenzoic acid as its β-O-D-glucoside. 13C NMR analysis of p-hydroxybenzoic acid β-O-glucoside showed that incorporation of shikimate proceeds with complete loss of carboxy group, i.e. exclusively via the prephenate-cinnamate pathway.Key Word Index - Lithospermum erythrorhizon; Boraginaceae; cell cultures; biosynthesis; 13C-labelling; naphthoquinones; shikonin; p-hydroxybenzoic acid; shikimic acid.