Reaction of 3β-chloro-5α,6α-epoxysteroids with trifluoroacetic acid

Article abstract of DOI:10.1007/BF02234929

It has been established that on the interaction of the 5α,6α-epoxysteroids (1a-c) with trifluoroacetic acid in chloroform the 6-trifluoroacetates of the 5α,6β-diols (2a-c) are formed in high yield. The alkaline hydrolysis of the trifluoroacetates (2a-c) leads to the corresponding diols (3a-c).