Chemistry of fluorinated vinamidinium salts: Novel reactions of β-trifluoromethyl vinamidinium salt with Grignard reagents

Article abstract of DOI:10.1016/S0022-1139(99)00036-6

β-Trifluoromethyl vinamidinium salt 1 reacted cleanly with a variety of Grignard reagents 2 in tetrahydrofuran under reflux for 3 h to produce a mixture of diastereoisomers (dl and meso) of the corresponding difluoromethylene compounds 3 in good to excellent yields.