Molecular chiral recognition in supercritical solvents

Article abstract of DOI:10.1016/S0040-4039(00)76525-7

The intensity of molecular chiral interactions resulting in differences between physical and chemical properties of diastereomeric molecules is solvent dependent. This difference makes it possible to separate the enantiomers of a given substance by using chiral agents. A solvent of suprcritical state was involved to study its influence on molecular chiral recognition. It was observed that the differences between the diastereomers in supercritical CO₂ are so big compared to traditional solvents that a novel, more efficient method for optical resolution can be developed, employing a variety of resolution agents in a much wider range than it was previously assumed.