Water-Soluble Calixarene as the First Man-Made Catalyst for Regioselective Cleavage of Ribonucleoside 2',3'-Cyclic Phosphate

Article abstract of DOI:10.1246/cl.1991.937

The P-O(2') bond of cytidine 2',3'-cyclic phosphate, an intermediate in RNA hydrolysis, is regioselectively cleaved at pH 2 by use of water-soluble calix<4>arene-5,11,17,23-tetrasulfonate.This is the first totally man-made mimic for the regioselective catalysis of ribonuclease.