
Chemistry Letters p. 937 - 940 (1991)
Update date:2022-08-11
Topics:
Komiyama, Makoto
Isaka, Kazuhiro
Shinkai, Seiji
The P-O(2') bond of cytidine 2',3'-cyclic phosphate, an intermediate in RNA hydrolysis, is regioselectively cleaved at pH 2 by use of water-soluble calix<4>arene-5,11,17,23-tetrasulfonate.This is the first totally man-made mimic for the regioselective catalysis of ribonuclease.
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