Pd-catalyzed direct arylation of nitro(pentafluorosulfanyl)benzenes with aryl bromides

Article abstract of DOI:10.1021/ol4023326

Limited methods for the synthesis of SF₅-substituted compounds significantly restrict their widespread application. A Pd-catalyzed direct arylation of nitro(pentafluorosulfanyl)benzenes with aryl bromides is reported. This protocol provides a facile and straightforward access to diversified SF₅-containing aryl derivatives. The notable features of this reaction are its synthetic simplicity, high reaction efficiency, and good regioselectivity.