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New Journal of Chemistry
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acetate:hexane (4:1 v/v) to get the desired semicarbazone linked-
triazoles 7 & 9 in 88-95 % yield.
Pharmacol. Res, 1998, 37, 17.
DOI: 10.1039/C9NJ00473D
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Conclusions
In summary, we have synthesized some semicarbazone-triazole
hybrid molecules through Cu(I)-catalyzed cycloaddition reaction of 28 Dutta S, Padhye S, Priyadarsini K I, Newton C, Bioorg. Med.
Chem. Lett. 2005, 15, 2738.
29 Rajak H, Thakur B. S, Kumar P, Parmar P, Sharma P. C, Kharya
R.V.M.D, Acta Pol. Pharm. 2012, 69, 253.
semicarbazone o/p-substituted alkyne with various organic azides
under green condition. The synthesized compounds exhibited
potent antibacterial activities against the tested bacterial strains.
An improvement in biological properties was observed by clubbing
semicarbazide units with suitably substituted 1,2,3-triazoles.
Further, the computational results of active semicarbazone-triazole
hybrid molecule 9b and its alkyne precursor 5 were in agreement
with the in vitro antimicrobial results.
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30 Rajak H, Jain D. K, Singh S, Singh A, Patel V. K, Veerasamy R,
Pawar R. S, Cent Nerv Syst Agents Med Chem. 2017, 17, 64.
31 Wiecek J, Kovala-Demertzi D, Ciunik Z, Wietrzyk J, Zervou M,
Demertzis M. A, Bioinorg Chem Appl. 2010, 12, 1.
32 Palanimuthu D, Wu Z, Jansson P. J, Braidy N, Bernhardt P. V,
Richardson D. R, Kalinowski D. S, Dalton Trans. 2018, 47
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7190.
Conflicts of interest
There are no conflicts to declare.
33 Angajala K. K, Vianala S, Macha R, Raghavender M, Pathi P. J,
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