Synthesis and pharmacological properties of some quinoline derivatives

Article abstract of DOI:10.1016/S0014-827X(98)00037-8

A series of 2-(2-thienyl)cinchoninic acids 3, their derivatives 5 and 4-(3-substituted-1,2,4-triazolo[3,4-b]- 1,3,4-thiaziazolo-6-yl)-2-(2-thienyl)quinolines 6 were synthesized. The structures of the newly synthesized compounds are confirmed by analytical, IR, NMR and mass spectral data. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anthelmintic activity. The results indicated that dinitrothiophene derivatives 5 are more active.