Russian Chemical Bulletin p. 98 - 100 (1994)
Update date:2022-08-29
Topics:
Kislyi, V. P.
Laikhter, A. L.
Ugrak, B. I.
Semenov, V. V.
It was shown that ethyl 2-nitroacetoacetate is a synthetic precursor of ethoxycarbonylnitrile oxide as well as of isoxazole- and isoxazoline-3-carboxylic acids and their esters.The elimination of acetic acid from ethyl 2-nitroacetoacetate occurs in a mixture of acetic acid and acetic anhydride in the presence of strong mineral acids, e.g., H2SO4, at room temperature and gives isoxazolines in yields of up to 85 - 91percent. - Key words: ethoxycarbonylnitrile oxide, isoxazoles, isoxazolines.
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