Efficient preparation of optically active (S)-(-)-3-methyl-γ-butyrolactone by catalytic asymmetric hydrogenation using chiral N-substituted pyrrolidinebisphosphine rhodium complexes

Article abstract of DOI:10.1248/cpb.39.2706

(S)-(-)-2-Methyl succinamic acid, which is a good precursor of (S)-(-)-3-methyl-γ-butyrolactone, can be prepared by homogeneous asymmetric hydrogenation of 2-methylene succinamic acid catalyzed by (2S,4S)-N-substituted-4-(diphenylphosphino)-2-[(diphenylphosphino)-meth yl]pyrrolidine-rhodium complexes. Various N-substituted pyrrolidine-bisphosphines were synthesized to find the optimum ligand for this purpose and to compare the effects of the N-substituents.

Full text of DOI:10.1248/cpb.39.2706

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service