Use of halomethyl resins to immobilize amines: An efficient method for synthesis of sulfonamides and amides on a solid support

Article abstract of DOI:10.1016/S0040-4039(97)01076-9

Methods for the synthesis of chloromethyl and bromomethyl equivalents of Wang's resin are described. To explore the utility of this acid clearable resin, amines were immobilized through the nitrogen atom, further functionalized, and then cleaved under acid conditions.