Preparation of Optically Active (4aα,8aβ)-Octahydro-4a-methyl-8-methylene-2(1H)-naphthalenone, a Key Intermediate for the Enantioselective Synthesis of Eudesmane Sesquiterpenes

Article abstract of DOI:10.1246/cl.1986.1103

The titled optically active methylene ketone was prepared in 45percent ee from 3-methyl-1,2-cyclohexanedione by use of a novel asymmetric Michael addition with (R,R)-(-)-2,3-butanediol as chiral auxiliary.