Fused pyrimidines. 7. Nucleosides of pyrimidopyrimidinediones and pteridinediones as potential chemotherapeutic agents

Article abstract of DOI:10.1002/jhet.5570340532

Several nucleoside derivatives of pyrimido [4,5-d]pyrimidine-2,4(1H,3H)- dione 1 and 2,4(1H,3H)-pteridinedione 2 were prepared. Treating the appropriate silylated nucleobase with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D- ribofuranose 3 in the presence of trimet