Ring D modifications of ellipticine. Part 2. Chlorination of ellipticine via its N-oxide and synthesis and selective acetylation of 5,6,11-trimethyl-5H-benzo[b]carbazole

Article abstract of DOI:10.1016/S0040-4020(01)85018-3

The N-oxide of ellipticine can be used for the introduction of a chlorine atom at carbon-3 of the ellipticine nucleus. According to model studies with 5,8-dimethylisoquinoline-N-oxide the reaction is guided both by steric hindrance and by nitrogen-6 of th