A Highly Convenient Route to Optically Pure α-Aminophosphonic Acids

Article abstract of DOI:10.1016/0040-4039(95)00750-7

Pure diastereomers, obtained simply and directly by reaction of hypophosphorous acid salts of (R)(+) or (S)(-) - N-α-methylbenzylamine with aldehydes, can be simultaneously deprotected and oxidised in one step to provide a highly convenient synthesis of α-aminophosphonic acids in high optical purity.