Chemistry of Heterocyclic Compounds p. 1176 - 1179 (1980)
Update date:2022-08-17
Topics:
Karpeiskii, M. Ya.
Mikhailov, S. M.
Tsieminya, A. S.
Ziderman, A. A.
Kravchenko, I. M.
et al.
A number of alkoxyalkyl derivatives of 5-fluorouracil were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with α-chloro ethers or by the addition of 5-fluorouracil to vinyl ethers.It was established that the synthesized compounds are capable of increasing the lifetimes of mice with L-1210 leukemia and La hemocytoblastosis.The UV and NMR spectra of the synthesized compounds are presented.
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