Optical Resolution of (+/-)-Phenylsuccinic Acid by Using (-)-Proline as Resolving Agent

Article abstract of DOI:10.1246/bcsj.60.824

A solution of equimolar mixture of (+/-)-phenylsuccinic acid ((+/-)-PSA) and (-)-proline ((-)-Pro) in ethanol or its suspension in 2-propanol selectively gave a salt composed of 1-molar amount of PSA and 2-molar amount of (-)-Pro.The salt purified gave (+)-PSA with an optical purity of about 100percent.A salt composed of equimolar amounts of PSA and (-)-Pro was obtained from the ethanolic mother liquor, and gave (-)-PSA with an optical purity of 98percent.