
Tetrahedron Letters p. 2177 - 2178 (1998)
Update date:2022-08-17
Topics:
Harger, Martin J. P.
When Ph2P(S)NHOCOPh labelled with 18O in the C=O group (43% isotopic enrichment) reacts with NaOMe in MeOH, the products are unlabelled Ph2P(O)NH2 and labelled PhCO2Me (43% isotopic enrichment). By implication, the intermediate Ph2P(O)NHSCOPh that results from rearrange- meat (translation of O and S atoms) has all the label in the C=O group and none in the P=O group.
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