Synthesis and in silico and in vitro evaluation of trimethoxy-benzamides designed as anti-prion derivatives

DOI: 10.1007/s00044-019-02441-2

Source and publish data:

Medicinal Chemistry Research p. 2128 - 2141 (2019)

Update date:2022-08-17

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Authors:

Concei??o, Raissa A.

Ascari, Lucas M.

Ferreira, Natália C.

Goes, Carolina F.

Matos, Carolina O.

Pinheiro, Anderson S.

Alves, Marina A.

Souza, Alessandra M. T.

Maia, Rodolfo C.

Caughey, Byron

Cordeiro, Yraima

Barbosa, Maria Letícia C.

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Article abstract of DOI:10.1007/s00044-019-02441-2

Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are neurodegenerative disorders which affect mammals, including the human species, and arise after the conversion of the monomeric cellular prion protein (PrP^C) int

Full text of DOI:10.1007/s00044-019-02441-2

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