Diastereoselective Synthesis of α-Bromo amides leading to Diastereomerically Enriched α-Amino-, α-Hydroxy- and α-Thiocarboxylic Acid Derivatives

Article abstract of DOI:10.1016/0957-4166(95)00032-K

α-Bromo amides derived from Oppolzer's camphorsultam can be prepared diastereoselectively starting from racemic α-bromo acids, and undergo epimerisation under appriopriate conditions leading to an enhanced d.e..By reacting the individual isomers or the mi