Xanthones, triterpenes and a biphenyl from Kielmeyera coriacea

Article abstract of DOI:10.1016/S0031-9422(97)00731-0

Analysis of the dichloromethane extracts of Kielmeyera coriacea leaves and stems by high performance liquid chromatography coupled with a photodiode array detector (LC-UV) and thermospray liquid chromatography-mass spectrometry (TSP/LC-MS) revealed the presence of several xanthones. Phytochemical investigation of these extracts resulted in the isolation and identification of ten xanthones, one biphenyl and two triterpenes. Their structures were established by chemical and spectroscopic methods (UV, EI- MS, D/CI-MS, ¹H NMR, ¹³C NMR, HMQC and HMBC). One xanthone and two triterpenes are new compounds. Four xanthones and the biphenyl exhibited antifungal activity against the plant pathogenic fungus Cladosporium cucumerinum, while two prenylated xanthones inhibited the growth of Candida albicans.