Preparation and in vitro antiprotozoan activity of new naphthoimidazolediones

Article abstract of DOI:10.1016/S0223-5234(97)84015-9

The original compound bearing the coplanar quinone and imidazole systems, 2-chloromethyl-4,9-dihydro-1-methyl-1H-naphtho[2,3-d] imidazol-4,9-dione reacted with various nitronate anions to afford, in moderate to rood yields, new naphtho- imidazolediones bearing a trisubstituted ethylenic double bond at the 2-position. These compounds were evaluated as potential antiprotozoan agents. Some derivatives were found to have a significant activity, but the naphthoquinone was found to be a less efficient pharmacophore than the nitro group.