Steroids p. 19 - 30 (1985)
Update date:2022-08-10
Topics:
Humber, David C.
Jones, Paul S.
Phillipps, Gordon H.
The four diastereomeric 3,16-diacetates 6, 9, 10 and 11 were prepared from gitoxin 1 by the routes shown in Schemes 1 and 2 and tested for inotropic activity in the isolated guinea-pig atrial preparation.In line with earlier findings in the digitoxigenin series, derivatives with a 3α-acetoxy function, viz 9 and 10, possessed high biological activity.
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Doi:10.1021/acs.jmedchem.0c02249
(2021)Doi:10.1590/S0103-50532010000700009
(2010)Doi:10.1016/S0031-9422(00)89952-5
(1971)Doi:10.1021/acscatal.0c01276
(2020)Doi:10.1021/acs.jafc.0c04131
(2020)Doi:10.1016/S0040-4020(02)01619-8
(2003)
