C2 Symmetric amines. III. An asymmetric synthesis of (S,S)-1,3-dialkyl isoindolines by sequential formamidine alkylation

Article abstract of DOI:10.1016/0040-4039(95)01182-H

Metalation-alkylation of isoindoline 5 in the form of its chiral formamidine, 6 leads to C₂-dialkylated derivatives in high ee's.