λ-Radiolysis of mitomycin C derivatives

Article abstract of DOI:10.1002/jhet.5570310109

The λ-Radiolysis reactions of mitomycin C (1) and its derivatives were studied in the hope of developing a radiation-induced drug (RID). The λ- radiolysis reactions were carried out in aqueous solutions under the condition where hydrated electron (e^-(aq)) was generated as a principal reactive species. The competitive λ-radiolysis studies revealed that the rate constants for the reactions of 1 with e^-(aq) at room temperature was 3.6 x 10¹⁰ dm³ mol^-1s^-1. Among mitomycin C derivatives, the 5H-6- alkoxyimino derivatives 11 and 12, and compound 13 in which ring A of 1 has the 4-hydroxy-6-hydroxyimino structure cleaved to give 1. The mechanic aspect of these λ-radiolysis reactions is discussed.