Regiochemical Control in the Conjugate Addition of Dithianylidene Anions: Total Syntheses of (+-)-Aromatin and (+-)-Confertin

DOI: 10.1021/jo00317a042

Source and publish data:

Journal of Organic Chemistry p. 825 - 827 (1981)

Update date:2022-08-11

Topics:

Authors:

Ziegler, Frederick E.

Fang, Jim-Min

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Article abstract of DOI:10.1021/jo00317a042

The lithium anion of the dithiane of (E)-2-methyl-2-butenal has been shown to undergo a highly regioselective Michael addition-alkylation sequence.Subsequent stereoselective transformations of the derived adduct have culminated in syntheses of the pseudoguaianolides (+-)-aromatin and (+-)-confertin.

Full text of DOI:10.1021/jo00317a042

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