Descarboxylysergic acid (9,10 didehydro 6 methylergoline)

Article abstract of DOI:10.1021/jm00249a011

dl Descarboxylysergic acid (2) has been synthesized by 2 routes from 9,10 didehydro 2,3 dihydro 8β hydroxy 6 methylergoline (3). Since 2 shows many of the pharmacological activities of other ergot derivatives, a side chain at the 8 position in an ergoline is not essential for biological activity. The unique rigid arylethylamine moiety in this class is probably the key structural feature.