Tetrahedron Letters p. 2607 - 2610 (1995)
Update date:2022-08-11
Topics:
Oppolzer, Wolfgang
Radinov, Rumen N.
Brabander, Jef De
ω-Alkynal ester 3, prepared from (S)-propylene oxide 4, yields the macrocyclic (6R)-allylic alcohol 2 (60percent yield, 83percent d.e.) in one operation via monohydroboration, boron/zinc-transmetalation and (-)-DAIB "catalyzed" intramolecular alkenylzinc/aldehyde addition.Introduction of the C(2)-C(3) double bond by selenoxide elimination (2 -> 8), hydroxy-directed epoxidation (8 -> 9), acetate assisted α-epoxide opening (10 -> 12) and acidic methanolysis provides pure (+)-aspicilin (1) in 22percent yield from 4.
View MoreTai zhou world Pharm & Chem Co., Ltd
Contact:+86-576-85301198
Address:Rome 1001,wangjiang plaza,unti 2,jinshan east Road linhai,zhejiang,china
SHIJIAZHUANG HENRYTE CHEMICALS CO,.LTD(expird)
Contact:+86-311-85208698 311-80837698
Address:NO.166, yuhua west road, SHIJIAZHUANG, China
Henan PURUI Pharmaceutical Co., Ltd.
website:http://www.puruipharm.com
Contact:17739583555
Address:Yezhuangqiao,Xihua town, Henan province
AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD
Contact:+86-25-86883560 15951806178
Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Triumph International Development Limilted
website:http://www.jiashengchem.cn/
Contact:+86-536-7971999
Address:Yinhai Road,Shouguang
Doi:10.1055/s-0035-1560830
(2016)Doi:10.1080/10610278.2019.1624748
(2019)Doi:10.1021/ja50001a044
(1969)Doi:10.1002/jhet.5570430128
(2006)Doi:10.1039/c1dt10951k
(2011)Doi:10.1016/j.molliq.2021.115946
(2021)