Synthesis and Biological Evaluation of Some 5-Nitro- and 5-Amino Derivatives of 2′-Deoxycytidine, 2′,3′-Dideoxyuridine, and 2′,3′-Dideoxycytidine

Article abstract of DOI:10.1081/NCN-120026403

In this article, we describe the synthesis of 5-nitro-1-(2-deoxy-α -D-erythro-pentofuranosyl)cytosine (4α), 5-nitro-1-(2-deoxy-β -D-erythro-pentofurano syl)cytosine (4β), 5-amino-1-(2-deoxy-α -D-erythro-pentofuranosyl)cytosine (5α), 5-nitro-1-(2-deoxy-β -D-erythro-pentofuranosyl)cytosine (5β), 5-nitro-1-(2,3-dideoxy-β -D-ribofuranosyl)uracil (6β), 5-amino-1-(2,3-dideoxy-α, β-D-ribofuranosyl)uracil (7), 5-nitro-1-(2,3-dideoxy-α,β -D-ribofuranosyl)cytosine (8) and 5-amino-1-(2,3-dideoxy-β -D-ribofuranosyl)cytosine (9β). The prepared compounds were tested for their activity against HIV and HBV viruses, but they did not show significant activity.