Synthesis of pyridylglyoxylic acid derivatives via a palladium-catalysed double carbonylation of iodopyridines

Article abstract of DOI:10.1016/S0040-4039(99)00596-1

4-Iodopyridines react with CO and HNEt₂ or 2-BuOH/NEt₃ in the presence of a catalytic amount of PdCl₂(PPh₃)2 to give the corresponding α-keto amides and esters in fair to high yields.