10.1002/anie.201901927
Angewandte Chemie International Edition
COMMUNICATION
appears to block access to one face of the prochiral a-carbon Acknowledgements
atom. It appears plausible that an enolate derived from 28 would
This work was supported by a grant from the US National
Institutes of Health (NIGMS GM-R35-127140).
have a similar conformation and this would allow an electrophile
to approach only from the less hindered face, thereby accounting
for the excellent anti diastereoselectivity.23
Keywords: Boron • Cross-Coupling • Nickel • Catalysis
In conclusion, we have described a catalytic cross-coupling
between four-coordinate boron "ate" complexes and carbonyl
electrophiles. This process provides a simple route to b-
trialkylboryl carbonyls which exhibit uncommon and synthetically
useful reactivity.
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