Stereoselective synthesis of α-L-bicarbocyclic nucleosides as potential antiviral drugs

DOI: 10.1016/S0040-4039(98)02137-6

Source and publish data:

Tetrahedron Letters p. 9175 - 9178 (1998)

Update date:2022-08-11

Topics:

Authors:

Demaison, Christine

Hourioux, Christophe

Roingeard, Philippe

Agrofoglio, Luigi A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(98)02137-6

Synthesis of hitherto unknown carbocyclic α-L-isomeric bicyclo[3.1.0]hexyl nucleosides (8-11) is described. The key intermediate 7 was synthesized in seven steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions. Compounds 8-11 were evaluated as anti-HBV agents in HepG2T14 cells.

Full text of DOI:10.1016/S0040-4039(98)02137-6

Products guided by the article

Product name:2-Cyclopentene-1-ethanol, 5-hydroxy-, (1S,5R)-

Cas No:54483-54-4

R&D Labs maybe for 54483-54-4

Shanghai Yuantai Chemical Products Co., Ltd

Contact:021--66129803

Address:Chengyin Road,Shanghai,China
Nowa pharmaceuticals Co., LTD

Contact:86-512-69362780,69362785

Address:No.69 Weixin Road,Weiting Town,Suzhou Industrial Park
WEIFANG DERUN CHEMICAL CO.,LTD

Contact:86-536-8956886

Address:weifang
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd

Contact:+86-791-86899381

Address:Nanchang, Jiangxi, China
Shanghai Mio Chemical Co., Ltd

Contact:0086 21- 64401188-622

Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China

Relevant to this article

Synthesis, spectroscopic and electrochemical characterisation of binuclear dioxomolybdenum complexes derived from disalicylaldehyde succinoyldihydrazone

Doi:10.1016/j.molstruc.2012.06.053
(2012)
1,3-Dialkyl-3-acyltriazenes: Products and Rates of Decomposition in Acidic and Neutral Solutions

Doi:10.1021/jo00028a047
(1992)
High-vacuum pyrolysis of 1,1,1-trifluoro-2-bromo-2-chloroethane. IR spectrum of 1,1,1-trifluoro-2-chloroethyl radical in an argon matrix

Doi:10.1007/BF02494527
(1998)
Microwave-assisted synthesis of chiral nopinane-annelated pyridines by condensation of pinocarvone oxime with enamines promoted by FeCl₃ and CuCl₂

Doi:10.1080/00397911.2013.877145
(2014)
Doi:10.1016/S0277-5387(00)83820-6
(1989)
A metal-free route to CF₃-containing oxindoles by PhI(OAc) ₂-mediated trifluoromethylation of N-arylacrylamides with TMSCF ₃

Doi:10.1002/ejoc.201301512
(2014)

Article Doi