Stereoselective synthesis of α-L-bicarbocyclic nucleosides as potential antiviral drugs

DOI: 10.1016/S0040-4039(98)02137-6

Source and publish data:

Tetrahedron Letters p. 9175 - 9178 (1998)

Update date:2022-08-11

Topics:

Authors:

Demaison, Christine

Hourioux, Christophe

Roingeard, Philippe

Agrofoglio, Luigi A.

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Article abstract of DOI:10.1016/S0040-4039(98)02137-6

Synthesis of hitherto unknown carbocyclic α-L-isomeric bicyclo[3.1.0]hexyl nucleosides (8-11) is described. The key intermediate 7 was synthesized in seven steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions. Compounds 8-11 were evaluated as anti-HBV agents in HepG2T14 cells.

Full text of DOI:10.1016/S0040-4039(98)02137-6

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