Tetrahedron Letters p. 9175 - 9178 (1998)
Update date:2022-08-11
Topics:
Demaison, Christine
Hourioux, Christophe
Roingeard, Philippe
Agrofoglio, Luigi A.
Synthesis of hitherto unknown carbocyclic α-L-isomeric bicyclo[3.1.0]hexyl nucleosides (8-11) is described. The key intermediate 7 was synthesized in seven steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions. Compounds 8-11 were evaluated as anti-HBV agents in HepG2T14 cells.
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