Stereoselective synthesis of α-L-bicarbocyclic nucleosides as potential antiviral drugs

DOI: 10.1016/S0040-4039(98)02137-6

Source and publish data:

Tetrahedron Letters p. 9175 - 9178 (1998)

Update date:2022-08-11

Topics:

Authors:

Demaison, Christine

Hourioux, Christophe

Roingeard, Philippe

Agrofoglio, Luigi A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(98)02137-6

Synthesis of hitherto unknown carbocyclic α-L-isomeric bicyclo[3.1.0]hexyl nucleosides (8-11) is described. The key intermediate 7 was synthesized in seven steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions. Compounds 8-11 were evaluated as anti-HBV agents in HepG2T14 cells.

Full text of DOI:10.1016/S0040-4039(98)02137-6

Products guided by the article

Product name:2-Cyclopentene-1-ethanol, 5-hydroxy-, (1S,5R)-

Cas No:54483-54-4

R&D Labs maybe for 54483-54-4

Chengdu Chengnuo New-Tech Co., Ltd

Contact:0086-028-85749078

Address:4 Jiuyang road,Jiulong industrial port,Chengdu, China
Anhui Gusheng Import&Export CO.,LTD

Contact:86-551-63662296

Address:Jinzhai Road NO.162 ,hefei, china
AllyChem Co., Ltd., Dalian, China（BBChem）

Contact:+86-411-62313318/62313328

Address:No.5 of Jinbin Road, Jinzhou New District, Dalian City, Liaoning Province, P.R.China
Dezhou Longteng Chemical Co., Ltd.

website:http://www.sodium-methoxide.cn/

Contact:0086-18866052283

Address:Xinhua Industrial Zone, Dezhou City, Shandong Province, China
Shanghai Synmedia Chemical Co., Ltd

Contact:+86-21-38681880

Address:6th Floor, 11A Building, No.528 Ruiqing Road, Heqing town, Pudong new district, Shanghai China

Relevant to this article

Synthesis, spectroscopic and electrochemical characterisation of binuclear dioxomolybdenum complexes derived from disalicylaldehyde succinoyldihydrazone

Doi:10.1016/j.molstruc.2012.06.053
(2012)
1,3-Dialkyl-3-acyltriazenes: Products and Rates of Decomposition in Acidic and Neutral Solutions

Doi:10.1021/jo00028a047
(1992)
High-vacuum pyrolysis of 1,1,1-trifluoro-2-bromo-2-chloroethane. IR spectrum of 1,1,1-trifluoro-2-chloroethyl radical in an argon matrix

Doi:10.1007/BF02494527
(1998)
Microwave-assisted synthesis of chiral nopinane-annelated pyridines by condensation of pinocarvone oxime with enamines promoted by FeCl₃ and CuCl₂

Doi:10.1080/00397911.2013.877145
(2014)
Doi:10.1016/S0277-5387(00)83820-6
(1989)
A metal-free route to CF₃-containing oxindoles by PhI(OAc) ₂-mediated trifluoromethylation of N-arylacrylamides with TMSCF ₃

Doi:10.1002/ejoc.201301512
(2014)

Article Doi