Tetrahedron Letters p. 643 - 644 (1999)
Update date:2022-08-11
Topics:
Lee, Byung H.
Clothier, Michael F.
Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.
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Doi:10.1021/ja00834a027
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