Selective reduction of secondary amides to amines in the presence of tertiary amides

DOI: 10.1016/S0040-4039(98)02509-X

Source and publish data:

Tetrahedron Letters p. 643 - 644 (1999)

Update date:2022-08-11

Topics:

Authors:

Lee, Byung H.

Clothier, Michael F.

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Article abstract of DOI:10.1016/S0040-4039(98)02509-X

Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.

Full text of DOI:10.1016/S0040-4039(98)02509-X

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