ASYMMETRIC MICHAEL REACTION USING MACROCYCLIC LACTOSE DERIVATIVES AS CHIRAL CATALYSTS

Article abstract of DOI:10.1016/S0040-4039(00)84847-9

Macrocyclic lactose derivates complexed to potassium bases catalysed the Michael addition of phenyl- and naphthylacetic esters to methyl acrylate to give the corresponding adducts in enantiomeric excess ranging from 20 to 7o percent.