Journal of Pharmaceutical Sciences p. 514 - 520 (1982)
Update date:2022-08-11
Topics:
Bodor
Sloan
Progesterone and testosterone are natural soft drugs, but to be used as drugs, their fast and facile metabolism must be prevented and their delivery controlled. A prodrug-soft drug combination can serve this purpose. Thiazolidines of testosterone, testosterone 17-proprionate and progesterone were synthesized from the reaction of cysteine alkyl esters, N-methylaminoethanethiol, and mercaptamine and their hydrochlorides with the appropriate steroids. The thiazolidines function as bioreversible derivatives of the parent steroids.
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Doi:10.1039/c39830000041
(1983)Doi:10.1002/hlca.19760590328
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(1999)Doi:10.1016/j.procbio.2012.04.021
(2012)Doi:10.3390/molecules25092188
(2020)Doi:10.1007/BF00714070
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