Biosynthesis of β-(isoxazolin-5-on-2-yl)alanine, the precursor of the neurotoxic amino acid β-N-oxalyl-L-α,β-diaminopropionic acid

Article abstract of DOI:10.1248/cpb.39.3376

β-(Isoxazolin-5-on-2-yl)alanine (BIA), a biosynthetic precursor of the neurotoxic amino acid β-N-oxalyl-L-α,β-diaminopropionic acid (ODAP), was confirmed to be derived from O-acetyl-L-serine (OAS) and isoxazolin-5-one by cysteine synthase in higher plants. Some properties of this enzyme in the biosynthesis of BIA are described.

Full text of DOI:10.1248/cpb.39.3376

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