Solvolysis of a substituted imidazoline, mazindol

Article abstract of DOI:10.1002/jps.2600641118

Hydrolysis of mazindol to form 2 (2 aminoethyl) 3 (p chlorophenyl) 3 hydroxyphthalimidine was followed spectrophotometrically in aqueous solutions at temperatures between 37 and 70°, pH values up to 7.6, and an ionic strength of 0.2. The effects of acetate, formate, and phosphate buffers as well as ionic strength on the observed rate constants were investigated. An interesting nonlinear dependency of the k(obs) with buffer concentration was noted. The velocity constants declinded with increasing hydrogen ion concentration; the log k pH profile and rate law are given along with other relevant data.