Tetrahedron Letters p. 4219 - 4220 (1997)
Update date:2022-08-30
Topics:
Bekaert, Alain
Andrieux, Jean
Plat, Michel
Brion, Jean-Daniel
A high yield synthesis of various 2-hydroxy-1,4-naphtoquinones was achieved by SeO2 oxidation of 1-tetralones into the corresponding 1,2-quinones, followed by heterogeneous phase KO2 mediated oxidation. Application of this synthesis to 5,7,8-trimethoxy-1-tetralone gave 2-hydroxy-5,7,8-trimethoxy-1,4-naphtoquinone 3d or monpain trimethylether.
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