Prostaglandins and congeners. 14. Synthesis and bronchodilator activity of dl 16,16 trimethyleneprostaglandins

DOI: 10.1021/jm00218a010

Source and publish data:

Journal of Medicinal Chemistry p. 1042 - 1047 (1977)

Update date:2022-08-16

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Authors:

Skotnicki

Schaub Schaub

Weiss Weiss

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Article abstract of DOI:10.1021/jm00218a010

The interesting bronchodilator activity of novel dl-16,16-trimethyleneprostaglandin congeners and their preparation via the conjugate addition of the appropriate vinyl lithiocuprate reagent to several cyclopentenones are described. Also discussed is the preparation of the key intermediate vinyl iodide 7.

Full text of DOI:10.1021/jm00218a010

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