
Tetrahedron Letters p. 5563 - 5564 (1987)
Update date:2022-08-24
Topics:
Bashiardes, George
Davies, Stephen G.
Stereoselective alkylation of (R)-<(ε5-C5H5)Fe(CO)(PPh3)COCH2CH3> with bromomethyl-t-butyl sulphide, followed by oxidative decomplexation in the presence of L-proline t-butyl ester gave, after deprotection, (-)-Captopril enantiomerically and diastereomerically pure in an overall yield of 59percent.
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